Targeted Muscle Reinnervation at the Time of Major Limb Amputation Reduces Long-Term Use and Dependence for Opioid Analgesic Therapy
Primary TMR at the time of major limb amputation significantly reduces long-term opioid use and dependence, particularly in patients with limb-threatening ischemia, without increasing the risk of stump-related complications. These findings support the broader adoption of TMR to improve postoperative outcomes in amputees.
Authors
- Neill Y. Li (ORCID: https://orcid.org/0000-0001-9149-4859)
- Eliana B. Saltzman (ORCID: https://orcid.org/0000-0003-2541-3541)
- Kevin M. Klifto (ORCID: https://orcid.org/0000-0002-2742-4319)
- Julie Anderson (ORCID: https://orcid.org/0000-0003-4136-9229)
- Jackson Cathey (ORCID: https://orcid.org/0009-0007-6230-5044)
- Sean Li (ORCID: https://orcid.org/0000-0002-0492-1179)
Institutions
- Duke University (US)
- University of Missouri (US)
Publication Details
- Journal
- Annals of Surgery
- Published
- 2025-03-19
- DOI
- https://doi.org/10.1097/sla.0000000000006697
- Citations
- 1
- Primary Topic
- Pain Management and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.19