Halogenation of arenes using alkali metal halides/Fe(NO <sub>3</sub> ) <sub>3</sub> ·9H <sub>2</sub> O at room temperature
A simple, efficient and environmentally friendly methodology for the halodecarboxylation of anisole analogues using Fe(NO<sub>3</sub>)<sub>3</sub>·9H<sub>2</sub>O/KBr or NaI at room temperature was developed. In this method, most substrates with an electron-donating group afforded corresponding products in good to excellent yields, whereas those with an electron-withdrawing group afforded low to moderate yields. More importantly, this protocol was also applicable for gram-scale synthesis. It is hoped that this methodology will be highly useful in organic synthesis.
Authors
- Yiying Li (ORCID: https://orcid.org/0000-0003-3566-6008)
- Huanjun Xu (ORCID: https://orcid.org/0000-0002-2704-5108)
- Caicui Li
- Jinhui Wang
- Xiaodan Wang (ORCID: https://orcid.org/0009-0006-3799-950X)
- Xinmei Wang (ORCID: https://orcid.org/0009-0002-2131-5741)
- Cheng Yao (ORCID: https://orcid.org/0000-0003-2925-2773)
- Zhaoyan Huang (ORCID: https://orcid.org/0009-0000-4192-1760)
- Fangfang Pang
- Xiao Yan
Institutions
- Harbin Medical University (CN)
- Qiongtai Teachers College (CN)
- Hainan Medical University (CN)
Publication Details
- Journal
- RSC Advances
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ra00837a
- Primary Topic
- Vanadium and Halogenation Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hainan Province
- Hainan Association for Science and Technology
- National Science and Technology Major Project