Pharmacokinetics of Milbemycin Oxime in Pekingese Dogs after Single Oral and Intravenous Administration
These findings demonstrate that the milbemycin oxime nanoemulsion is absorbed more rapidly and completely, with significantly higher bioavailability than the tablet form. This suggests that the nanoemulsion could effectively overcome the issues of poor diffusion and low bioavailability associated with tablet formulations, positioning it as a promising alternative to traditional milbemycin oxime tablets.
Authors
- Xing‐Ping Li (ORCID: https://orcid.org/0000-0001-6352-4627)
- Ze‐En Li
- Minghui Duan (ORCID: https://orcid.org/0000-0003-2130-6300)
- Yan‐Ni Zhang
- Yang‐Guang Jin
- Fan Yang (ORCID: https://orcid.org/0000-0001-8847-1031)
- Yue Liu (ORCID: https://orcid.org/0000-0002-0084-863X)
- Yan Dai (ORCID: https://orcid.org/0000-0003-0177-3745)
Institutions
- Henan University of Science and Technology (CN)
Publication Details
- Journal
- Veterinary Medicine and Science
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/vms3.70312
- Citations
- 1
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 1.39