Rhus coriaria (Sumac) induces autophagic cell death and inhibits mTOR, p38MAPK and STAT3 pathways in 5fluorouracil-resistant colorectal cancer cells
Collectively, our findings highlight that RCE is a source of phytochemicals that can be used as anticancer agents for 5FU-resistant CRC.
Authors
- Kholoud Arafat (ORCID: https://orcid.org/0000-0003-0549-7223)
- Adil Farooq Wali (ORCID: https://orcid.org/0000-0003-1555-2820)
- Soumaya Khaldi
- Samir Attoub
- Ali Hussein Eid (ORCID: https://orcid.org/0000-0003-3004-5675)
- Yusra Al Dhaheri
- Zohra Nausheen Nizami (ORCID: https://orcid.org/0000-0003-2920-4173)
- Rabah Iratni
- Mazoun Al Azzani
- Rym Magramane (ORCID: https://orcid.org/0009-0006-6257-2575)
- Shamaa Abdul Samad
Institutions
- United Arab Emirates University (AE)
- Qatar University (QA)
- Ras al-Khaimah Medical and Health Sciences University (AE)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-03-19
- DOI
- https://doi.org/10.3389/fphar.2025.1542204
- Citations
- 2
- Primary Topic
- Medicinal Plant Research
- Type
- article
- Field-Weighted Citation Impact
- 3.50
Funders
- United Arab Emirates University