Study on the Mechanism of QRICH1 Mediating PRMT1 to Regulate the Arginine Methylation Modification of cGAS to Promote Arsenics-Induced Pyroptosis in Hepatocellular Carcinoma Cells
NaAsO2 inhibits the expression of the QRICH1-PRMT1 axis, activates cGAS-STING signaling pathway transduction, and induces pyroptosis in HCC cells, thereby increasing the infiltration of immune cells in liver cancer tissues.
Authors
- Jiayuan Zhang
- Ting Yang (ORCID: https://orcid.org/0000-0002-8182-0195)
- Bing Han (ORCID: https://orcid.org/0000-0001-7559-434X)
- Jun Yao (ORCID: https://orcid.org/0000-0002-4916-3412)
- Yingwan Zhang (ORCID: https://orcid.org/0009-0002-4717-7578)
- Tian Tian (ORCID: https://orcid.org/0000-0002-6103-1666)
- Shanshan Tian
- Rujia Xie (ORCID: https://orcid.org/0009-0007-4437-365X)
Institutions
- Guiyang Medical University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
- First People’s Hospital of Zunyi (CN)
- Guizhou Provincial People's Hospital (CN)
Publication Details
- Journal
- Journal of Hepatocellular Carcinoma
- Published
- 2025-03-01
- DOI
- https://doi.org/10.2147/jhc.s505266
- Citations
- 3
- Primary Topic
- Cancer-related gene regulation
- Type
- article
- Field-Weighted Citation Impact
- 2.42