The role of thiol-disulfide homeostasis in gouty arthropathy

Objective: Gout, the most common form of crystal-induced arthritis, is characterized by the accumulation of monosodium urate crystals within the joints. This study aimed to examine thiol-disulfide homeostasis in patients with gouty arthropathy during periods of acute attack and remission. Methods: A novel spectrophotometric technique was employed to assess native thiol (NT) and disulfide levels in gout patients and age-and sex-matched healthy controls. A total of 90 patients and 86 healthy individuals were evaluated using clinical and laboratory data extracted from their medical records. Results: The findings demonstrated that NT and total thiol (TT) levels in patients were significantly lower than in controls (p<0.001 for both). No significant differences in NT and TT levels were observed between acute attacks and remission periods (p>0.05). Conclusion: Alterations in thiol-disulfide homeostasis were evident in gout patients; however, these changes did not vary between periods of acute attack and remission.