A comprehensive strategy for the development of a multi-epitope vaccine targeting Treponema pallidum, utilizing heat shock proteins, encompassing the entire process from vaccine design to in vitro evaluation of immunogenicity
The vaccine developed in this study theoretically represents a safe and potent multi-epitope prophylactic strategy against <i>T. pallidum</i>, subject to further experimental validation to ascertain its actual protective efficacy.
Authors
- Youde Cao (ORCID: https://orcid.org/0000-0002-5961-9196)
- Xian Wu (ORCID: https://orcid.org/0000-0002-5679-8563)
- Kang Zheng (ORCID: https://orcid.org/0000-0001-7833-0593)
- Ranhui Li (ORCID: https://orcid.org/0000-0002-7585-6394)
- Ming Wang
- Xuefeng Wang (ORCID: https://orcid.org/0000-0001-8854-275X)
- Li Xu (ORCID: https://orcid.org/0000-0002-5867-0651)
- Jing Jiang (ORCID: https://orcid.org/0009-0007-8318-4747)
Institutions
- Hengyang Normal University (CN)
- Hunan Normal University (CN)
- Hunan Academy of Traditional Chinese Medicine (CN)
- Hunan Provincial People's Hospital (CN)
- University of South China (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-03-19
- DOI
- https://doi.org/10.3389/fmicb.2025.1551437
- Citations
- 5
- Primary Topic
- Syphilis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.82