DNA-PKcs Dysfunction Enhances the Antitumor Activity of Radioimmunotherapy by Activating the cGAS-STING Pathway in HNSCC
These findings suggest that targeting the DDR pathway may represent a promising therapeutic strategy and biomarker to improve the efficacy of radioimmunotherapy in HNSCC.
Authors
- Jing Lin (ORCID: https://orcid.org/0000-0002-4405-134X)
- Jiani Xiong (ORCID: https://orcid.org/0000-0001-6237-7514)
- Yaoming Wen (ORCID: https://orcid.org/0000-0002-6200-9292)
- Lizhu Chen (ORCID: https://orcid.org/0000-0002-9881-2976)
- Yu Chen (ORCID: https://orcid.org/0000-0002-9661-3914)
- Bin Lan (ORCID: https://orcid.org/0000-0003-3121-7643)
- Chuanben Chen (ORCID: https://orcid.org/0000-0002-5994-8897)
- Zengqing Guo
Institutions
- Fujian Medical University (CN)
- Fujian Institute of Microbiology (CN)
- Fujian Provincial Cancer Hospital (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-03-01
- DOI
- https://doi.org/10.2147/jir.s497295
- Citations
- 4
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 3.19