The role of Piezo1 in bone marrow stem cells in response to elevated intraosseous pressure on regulating osteogenesis and angiogenesis of steroid-induced osteonecrosis of the femoral head
Currently, many mechanisms of the impact of elevated intraosseous pressure on osteonecrosis of the femoral head are still in the basic theoretical research stage, and we hope to translate them into clinical applications as soon as possible. We discovered that targeting Piezo1 curb further increases in intraosseous pressure, alleviating the damaging effects of glucocorticoids on stem cells and blood vessels, which exerting great significance in treatment of early stage SONFH.
Authors
- Xiao Lv
- Ruoyu Wang (ORCID: https://orcid.org/0000-0002-3644-1284)
- Yuxi Wang
- Ping Wang (ORCID: https://orcid.org/0000-0001-5720-8687)
- Bo Wang (ORCID: https://orcid.org/0000-0002-9620-3413)
- Zilin Li (ORCID: https://orcid.org/0000-0002-0269-3280)
- Yong Feng (ORCID: https://orcid.org/0000-0002-9897-5679)
- Lizhi Han
Institutions
- Union Hospital (HK)
- Bengbu Medical College (CN)
- Wuhan No.1 Hospital (CN)
- First Affiliated Hospital of Bengbu Medical College (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Orthopaedic Translation
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1016/j.jot.2025.01.008
- Citations
- 4
- Primary Topic
- Erythrocyte Function and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 4.66
Funders
- National Natural Science Foundation of China