Novel activity assay for botulotoxin A1 detection using functionalized chips and matrix-assisted laser desorption/ionization mass spectrometry
This study reports the <i>in-situ</i> detection of botulotoxin A1 using functionalized MALDI chips. The advantages of the MALDI chip technology include speed, robustness, cost-effectiveness, and possible automatization.
Authors
- Jiří Dresler (ORCID: https://orcid.org/0000-0003-1449-6038)
- Z. Kalaninová (ORCID: https://orcid.org/0000-0002-1399-6404)
- Michael Volný (ORCID: https://orcid.org/0000-0001-7456-5408)
- Petr Novák (ORCID: https://orcid.org/0000-0001-8688-529X)
- Petr Pompach (ORCID: https://orcid.org/0000-0002-0606-0851)
- Josef DVOŘÁK (ORCID: https://orcid.org/0009-0006-6359-0257)
Institutions
- Czech Academy of Sciences (CZ)
- Charles University (CZ)
- University of Chemistry and Technology, Prague (CZ)
Publication Details
- Journal
- Expert Review of Proteomics
- Published
- 2025-03-19
- DOI
- https://doi.org/10.1080/14789450.2025.2482933
- Primary Topic
- Botulinum Toxin and Related Neurological Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Health Research
- Technology Agency of the Czech Republic