Defining the Blood Cytokine Profile in Asthma to Understand Asthma Heterogeneity
Systemic inflammation in asthma is complex. Patients had multiple overlapping inflammatory profiles suggesting several disease mechanisms. Genetic risk factors for moderate-severe asthma confirmed previous associations with childhood onset of asthma.
Authors
- Tricia M. McKeever (ORCID: https://orcid.org/0000-0003-0914-0416)
- Liam Gabriel Heaney (ORCID: https://orcid.org/0000-0002-9176-5564)
- Andrew Fogarty (ORCID: https://orcid.org/0000-0001-9426-977X)
- Adel Mansur (ORCID: https://orcid.org/0000-0002-8615-8778)
- Michael A. Portelli (ORCID: https://orcid.org/0000-0003-0821-4575)
- Dominick Shaw (ORCID: https://orcid.org/0000-0003-4106-8469)
- Iain D. Stewart (ORCID: https://orcid.org/0000-0002-1340-2688)
- Ratko Djukanović (ORCID: https://orcid.org/0000-0001-6039-5612)
- Zara Pogson
- Anoop Chauhan (ORCID: https://orcid.org/0000-0003-4044-6114)
- Neil C. Thomson (ORCID: https://orcid.org/0000-0003-1632-6630)
- Christopher Edward Brightling (ORCID: https://orcid.org/0000-0002-9345-4903)
- John W. Holloway (ORCID: https://orcid.org/0000-0001-9998-0464)
- Ian P. Hall (ORCID: https://orcid.org/0000-0001-9933-3216)
- Karina Bingham (ORCID: https://orcid.org/0000-0003-4844-4113)
- Yousra Khudran Alzahrani (ORCID: https://orcid.org/0000-0002-7384-5958)
- Rekha Chaudhuri (ORCID: https://orcid.org/0000-0001-8007-949X)
- Luisa Martı́nez-Pomares (ORCID: https://orcid.org/0000-0002-2331-127X)
- Peter Howarth (ORCID: https://orcid.org/0000-0003-0619-7927)
- John Blakey (ORCID: https://orcid.org/0000-0003-2551-8984)
- Ian Sayers (ORCID: https://orcid.org/0000-0001-5601-5410)
- Ananga Singapuri
Institutions
- Queen's University Belfast (GB)
- University of Nottingham (GB)
- University of Leicester (GB)
- Curtin University (AU)
- Lincoln County Hospital (GB)
- Glenfield Hospital (GB)
- Sir Charles Gairdner Hospital (AU)
- University Hospital Southampton NHS Foundation Trust (GB)
- United Lincolnshire Hospitals NHS Trust (GB)
- Portsmouth Hospitals NHS Trust (GB)
- Heartlands Hospital (GB)
- NIHR Southampton Biomedical Research Centre (GB)
- Nottingham Biomedical Research Centre (GB)
- University of Southampton (GB)
- Imperial College London (GB)
- University of Glasgow (GB)
Publication Details
- Journal
- Immunity Inflammation and Disease
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/iid3.70116
- Citations
- 2
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- National Institute for Health and Care Research