CHI3L1: a key driver in gastritis-to-cancer transformation
This study highlights CHI3L1 as a key gene driving the progression from gastritis to gastric cancer, primarily by activating the CD44-β-catenin pathway, which enhances malignant cell traits. CHI3L1 is mainly secreted by fibroblasts and dendritic cells, and its high levels are linked to poor gastric cancer prognosis.
Authors
- Yinan Yan (ORCID: https://orcid.org/0000-0002-8776-0656)
- Ming Dai (ORCID: https://orcid.org/0009-0004-6133-0035)
- Runhua Chen (ORCID: https://orcid.org/0000-0002-2413-1377)
- Yicong Li (ORCID: https://orcid.org/0000-0001-7905-4885)
- Xia Ding (ORCID: https://orcid.org/0000-0002-7346-942X)
- Xinyu Lu (ORCID: https://orcid.org/0000-0003-1617-1907)
- Jiena Chen
- Yanni Jia (ORCID: https://orcid.org/0000-0002-0952-0593)
- Jie Lin (ORCID: https://orcid.org/0000-0002-5198-2070)
- Huizhong Jiang (ORCID: https://orcid.org/0000-0003-1888-3131)
- Mengting Liao (ORCID: https://orcid.org/0000-0002-7444-2579)
- Tao Li (ORCID: https://orcid.org/0000-0002-5108-1774)
- Yan Chen (ORCID: https://orcid.org/0009-0004-6856-263X)
- Yihong Gong (ORCID: https://orcid.org/0000-0002-1793-5836)
- Yuan Li (ORCID: https://orcid.org/0000-0003-1694-5108)
Institutions
- University of Science and Technology of China (CN)
- Beijing University of Chinese Medicine (CN)
- Hefei National Center for Physical Sciences at Nanoscale (CN)
- Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-03-19
- DOI
- https://doi.org/10.1186/s12967-025-06352-2
- Citations
- 2
- Primary Topic
- Galectins and Cancer Biology
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation