Screening and analysis of programmed cell death related genes and targeted drugs in sepsis
Through bioinformatics approaches, this study successfully identified five genes (IRAK3, S100A9, TXN, NFATC2, and GSTO1) associated with programmed cell death in the context of sepsis. This research identified seven candidate drugs for sepsis treatment and established a methodological framework for predicting biomarkers and drug targets that could be applicable to other diseases.
Authors
- Zhiqiang Tang (ORCID: https://orcid.org/0000-0002-3058-1403)
- Juanjuan Song (ORCID: https://orcid.org/0000-0002-0634-0992)
- Kairui Ren
- Yi Wang (ORCID: https://orcid.org/0000-0002-2067-5465)
- Lili Zhang (ORCID: https://orcid.org/0000-0002-3601-0150)
- Lin Sun (ORCID: https://orcid.org/0000-0001-7079-9442)
- Dexin Zhang (ORCID: https://orcid.org/0009-0005-3235-7148)
- Ying Deng (ORCID: https://orcid.org/0000-0002-0363-686X)
Institutions
- Harbin Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Hereditas
- Published
- 2025-03-19
- DOI
- https://doi.org/10.1186/s41065-025-00403-w
- Citations
- 2
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 1.61