COMPUTATIONAL INSIGHTS INTO ANG (1-7) PEPTIDE ANALOGS: POTENTIAL ANTI-HYPERTENSIVE AGENTS THROUGH MOLECULAR DOCKING STUDIES

Hypertension remains a signicant global health concern, necessitating the development of novel therapeutic strategies. Angiotensin (1-7) [Ang (1-7)], a key component of the renin-angiotensin system (RAS), exerts vasodilatory and cardioprotective effects, making it a promising candidate for hypertension management. In this study, we employed molecular docking techniques to evaluate the binding afnity and interaction proles of manually synthesized and chemically modied Ang (1-7) peptide analogs, (ac)D-RVYIHP and DR-(me)V-YIHP, with key hypertensive regulatory targets. Docking results revealed strong and stable interactions between these synthetic Ang (1-7) analogs and the angiotensin receptors AT1R, AT2R, and MasR, suggesting a potential enhancement of antihypertensive effects. These computational insights provide a foundation for further experimental validation and drug development efforts targeting RAS modulation. Our ndings highlight the potential of Ang (1-7) analogs as promising lead compounds for novel antihypertensive therapies.