TMEM176B inhibits ovarian cancer progression by regulating EMT via the Wnt/β-catenin signaling pathway
TMEM176B inhibited EMT in OC cells by controlling the activation of the Wnt/β-catenin pathway. This mechanism underscored the diagnostic and prognostic potential of TMEM176B for OC and highlights its tumor-suppressive properties as a promising therapeutic candidate.
Authors
- Lili Yi (ORCID: https://orcid.org/0009-0000-6941-5325)
- Zhaona Song (ORCID: https://orcid.org/0000-0003-2061-3333)
- Xiaoping Ma (ORCID: https://orcid.org/0000-0003-3202-2514)
- Shaoda Ren
- Fengjiao Yuan (ORCID: https://orcid.org/0000-0002-2163-581X)
- Jian‐Yan Wei (ORCID: https://orcid.org/0000-0002-1061-8264)
- Dianlong Jia
- Xiaodong Jia (ORCID: https://orcid.org/0000-0001-8590-7477)
- Conghui Tian (ORCID: https://orcid.org/0000-0001-9546-9327)
- Xiang Wang (ORCID: https://orcid.org/0000-0002-2135-8576)
- Ruirui Zhang (ORCID: https://orcid.org/0000-0001-8928-4238)
- Feifei Wang (ORCID: https://orcid.org/0000-0001-7687-3412)
- Xiaobing Wang (ORCID: https://orcid.org/0000-0001-5044-3721)
- Xiaofeng Zhao (ORCID: https://orcid.org/0000-0002-3642-9920)
- Mingliang Gu
- Xuying Qin
- Lili Yan (ORCID: https://orcid.org/0000-0003-2870-0482)
Institutions
- Liaocheng University (CN)
- Liaocheng People's Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-03-19
- DOI
- https://doi.org/10.1186/s12967-025-06362-0
- Citations
- 4
- Primary Topic
- Cancer-related gene regulation
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- Natural Science Foundation of Shandong Province