Nontraditional Factors Influencing Cardiovascular Disease Risk: Correlation Among Framingham Risk Score, Body Composition Index, and Sleep‐Breathing Monitoring Index

To examine the correlation among body composition, sleep-breathing indicators, and Framingham risk score (FRS) to identify and amplify nontraditional factors that influence the risk of CVD in males, A total of 195 male participants underwent examinations for body composition and sleep-breathing monitoring. We compared the differences in individual factors across various FRS groups. We further conducted multiple linear regression analysis. A cutoff value of FRS ≥ 14 was utilized, and potential influencing factors were examined by logistic regression analysis. Statistical differences were observed in the levels of fasting blood glucose (FBG), CO₂, serum ferritin, hemoglobin (HB), and ECT/TBW among the FRS tripartite groups. However, no significant differences were found in AHI and MSpO₂. The multiple linear regression analysis revealed positive correlations between ECW/TBW and FBG with FRS (β = 0.324 and 0.324, p < 0.001), while HB and muscle/fat mass exhibited negative correlations with the score (β = -0.185 and - 0.169, p < 0.01). These five factors-ECW/TBW, FBG, HB, serum ferritin, and muscle/fat mass-collectively accounted for 28.6% of the variation in FRS. A higher ECW/TBW was significantly associated with FRS ≥ 14 (OR = 2.208, 95% CI: 1.503-3.244). Conversely, reduced levels of muscle/fat mass, HB, and basal metabolic rate (BMR) were significantly linked to moderate-to-high CVD risk (OR_ratio = 0.532, 95% CI: 0.284-0.996; OR_HB = 0.961, 95% CI: 0.932-0.991; OR_BMR = 0.997, 95% CI: 0.995-1.000). This study revealed correlations among ECW/TBW, HB, FBG, and muscle-to-fat mass ratio with the risk of CVD predicted using FRSs.