Consuming a High-Pectin Smoothie Has Different Effects on the Uric Acid Levels and Gut Microbiota of Healthy Women

Background/Objectives: Uric acid (UA) levels vary based on gender, but elevated UA levels are linked to various health conditions in both sexes. Methods: This study examined the impact of a high-pectin smoothie (11.6 g fiber/day) consumption for 3 weeks on UA levels and gut microbiota in 28 healthy women. Food diaries, stool, and blood samples were collected at baseline and after the smoothie consumption. Results: The participants with similar baseline UA levels showed divergent responses: UA levels increased in the 15th participant (UAI group) and decreased in the 13th (UAD group) post-intervention. Smoothie consumption increased Bacteroides in the UAD and Prevotella 9 in the UAI, contrasting with the baseline abundances, where Prevotella 9 was higher in the UAD and Bacteroides in the UAI group. Furthermore, the proportion of Faecalibacterium increased in the UAI group after smoothie consumption, equalizing the baseline difference with the UAD group. Conclusions: This research highlights the role of personalized dietary strategies, noting that the impact of increased pectin consumption on managing UA levels in women may rely on their baseline gut microbiota and fiber intake.