Benzodioxole Scaffold Incorporating Compound with Promising Anti-Fungal Potential: An Overview

This review focuses on the compounds with 1,3-benzodioxole scaffold and their antifungal potential. Different online sources including Google Scholar, Pubchem and Science Direct were used to collect information on benzodioxole containing compounds as antifungal agents from articles published between 2003 and 2022. The health threat posed by fungal infections to humans makes an ongoing search for more different antifungal agents necessary. Diverse heterocyclic moiety proves beneficial in fungal infection, among all of them benzodioxole incorporation into the compound was also found to be effective. The 1,3-benzodioxole or methylenedioxy benzene scaffold is highly adaptable, enabling a range of chemical modifications. The biophoric nature of this scaffold imparts distinctive pharmacological properties, contributing to its broad-spectrum activity. It was shown that the addition of heterocyclic moiety (e.g. primidinone, imidazole, thiazole, etc.), aliphatic linker, amide linker at position 5 and furthermore electron withdrawing group at position 6 enhances the antifungal potential against various phytopathogenic and human pathogenic fungi species. This review highlights the anti-fungal status of benzodioxole scaffold-containing compounds focusing on their efficacy against both phytopathogenic and human pathogenic fungal species. Additionally, the review discusses the structural modification and the future prospects of these compounds in antifungal therapy.