From Chronic Leg Ulcer to Squamous Cell Carcinoma: A Case Report

We present a case of a delayed diagnosis of cutaneous squamous cell carcinoma in the lower extremity developed in chronic non-healing tropical ulcers. An 80-year-old female patient was referred to the hospital due to complaints of a chronic non-healing ulcer in her left lower extremity, which she had since 2008. Despite receiving conservative treatment, the ulcer did not heal, and it continued expanding in size and developing questionable changes in the wound. Upon further examination and multiple biopsies obtained, Grade 2 invasive squamous cell carcinoma was confirmed with left inguinal lymphadenopathy. After three cycles of immunotherapy, clinical improvement was observed. However, after 10 cycles of treatment, disease progression occurred. The patient refused an amputation of the affected extremity; therefore, she was offered palliative care.