Analysis of the genetic evolution and recombination of the PRRSV-2 GP2 protein in China from 1996 to 2023

Porcine reproductive and respiratory syndrome virus (PRRSV) has caused significant losses and posed threats to the swine breeding industry. To date, there have been comparatively few studies on the GP2 protein of PRRSV-2, and consequently, many unanswered questions remain regarding its pathogenicity-associated mechanisms and effects. We collected 570 nucleotide sequences of the GP2 protein of this virus and used these data to perform multifaceted analytical work in order to facilitate the understanding of the genetic evolution of this virus and recombinant mutations. These provide basic data for the follow-up study of GP2 and lay a foundation for further in-depth studies of this virus and vaccine development.