Development of an Intratumoral Holmium Microsphere Injection Method in Ex Vivo Human Pancreatic Ductal Adenocarcinoma: A Preclinical Feasibility Study
Intratumoral injection of holmium-165 microspheres in ex vivo pancreatic ductal adenocarcinoma was feasible with adherence to injection parameters necessary for effective intratumoral deposition and minimal leakage. The injection system and parameters developed here provide a foundation for future studies on holmium-166 microsphere injections in pancreatic cancer patients, with the aim to improve local tumor control as a part of a multimodal therapy.
Authors
- Nienke Johanna Maria Klaassen (ORCID: https://orcid.org/0000-0001-8898-4005)
- Jurgen J. Fütterer (ORCID: https://orcid.org/0000-0001-6800-2879)
- Martijn W.J. Stommel (ORCID: https://orcid.org/0000-0002-4257-5254)
- Kees van Laarhoven (ORCID: https://orcid.org/0000-0003-2166-7931)
- J. Frank W. Nijsen (ORCID: https://orcid.org/0000-0001-7625-2253)
- Coen Ysbrand Willink (ORCID: https://orcid.org/0000-0001-6531-0358)
- Sjoerd Franciscus Maria Jenniskens
Institutions
- Radboud University Nijmegen (NL)
- Radboud University Medical Center (NL)
Publication Details
- Journal
- Cancers
- Published
- 2025-03-19
- DOI
- https://doi.org/10.3390/cancers17061028
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00