Precise Methylation Detection of Tumor Suppressor Gene Promoters by Magnetic Enrichment and Nano Silver Adduct–Promoted Surface‐Enhanced Raman Scattering (Small 11/2025)
Methylation Detection The gene adduct-modified silver cluster enables specific labeling of the methylation site on the tumor suppressor promoter. This cutting-edge system utilizes gene-hybridizable nanobeads for magnetic enrichment, ensuring targeted and efficient gene sample preparation. Silver-promoted surface-enhanced Raman scattering amplifies the 5-methyl cytosine signal, while localized hot spots around methylated and unmethylated promoters ensure precise methylation detection. More in article number 2407517, Yi-Hsin Chien, Wei-Peng Li, and co-workers.
Authors
- Wen‐Jyun Wang (ORCID: https://orcid.org/0009-0000-3359-6443)
- Yu‐Cheng Chang (ORCID: https://orcid.org/0000-0001-5474-680X)
- Yi‐Hsin Chien (ORCID: https://orcid.org/0000-0003-1331-6648)
- Weipeng Li (ORCID: https://orcid.org/0000-0001-9476-5028)
- Yu‐Wei Lin (ORCID: https://orcid.org/0009-0006-6910-2939)
- Shubham Singh (ORCID: https://orcid.org/0000-0002-4156-5900)
Institutions
- Kaohsiung Medical University (TW)
- Kaohsiung Medical University Chung-Ho Memorial Hospital (TW)
- Feng Chia University (TW)
- National Cheng Kung University (TW)
Publication Details
- Journal
- Small
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/smll.202570080
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00