Immunomodulatory effects of tumor Lactate Dehydrogenase C (LDHC) in breast cancer
Our findings suggest that targeting LDHC could enhance anti-tumor immune responses by modulating cytokine and chemokine secretion in addition to impairing immune checkpoint signaling. Further studies are required to elucidate the molecular mechanisms by which LDHC modulates immune responses in breast cancer.
Authors
- Adviti Naik (ORCID: https://orcid.org/0000-0001-5147-3869)
- Remy Thomas
- Abdulwahab Al-Khalifa
- Hanan Qasem (ORCID: https://orcid.org/0009-0007-6231-0628)
- Julie Decock (ORCID: https://orcid.org/0000-0002-4409-100X)
Institutions
- Carnegie Mellon University Qatar (QA)
- Hamad bin Khalifa University (QA)
- Qatar Foundation (QA)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-03-19
- DOI
- https://doi.org/10.1186/s12964-025-02139-6
- Citations
- 10
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 7.97
Funders
- Qatar Foundation