A sulfonated supramolecular host based on pillar[5]arene for succinylcholine-induced neuromuscular blockade reversal
A per-sulfonated pillar[5]arene (SP[5]A) is designed as a reversal agent to reverse neuromuscular blockade induced by succinylcholine (Sch) <i>via</i> host-guest recognition. SP[5]A can rapidly and specifically recognize and encapsulate Sch <i>in vivo</i> for elimination with a binding affinity as high as 10<sup>5</sup> M<sup>-1</sup>. SP[5]A mitigates Sch-induced adverse reactions including hyperkalemia, arrhythmias, and rhabdomyolysis.
Authors
- Danyu Xia (ORCID: https://orcid.org/0000-0001-6575-6448)
- M. Li (ORCID: https://orcid.org/0009-0008-5710-9513)
- Shaolong Qi (ORCID: https://orcid.org/0000-0003-2744-5387)
- Yujie Cheng
- Jianshi Du
- Rui Fei
- Zibin Zhang (ORCID: https://orcid.org/0000-0003-0293-0925)
Institutions
- Union Hospital (HK)
- Hangzhou Normal University (CN)
- Shanxi University (CN)
- Jilin University (CN)
- Union Hospital (CN)
- Jilin International Studies University (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc00728c
- Citations
- 1
- Primary Topic
- Supramolecular Chemistry and Complexes
- Type
- article
- Field-Weighted Citation Impact
- 0.94