Targeted siRNA Delivery Against RUNX1 Via tFNA: Inhibiting Retinal Neovascularization and Restoring Vessels Through Dll4/Notch1 Signaling
tFNAs-siRUNX1 is a promising delivery system for targeting RNV, inhibiting neovascularization, and restoring retinal vascular integrity, providing a potential therapeutic alternative to anti-VEGF treatments.
Authors
- Yunfeng Lin (ORCID: https://orcid.org/0000-0003-1224-6561)
- Xiaoyan Ding (ORCID: https://orcid.org/0000-0003-4936-3315)
- Xiaodi Zhou
- Linyan Zhang (ORCID: https://orcid.org/0000-0002-4713-8977)
- Qiong Wang (ORCID: https://orcid.org/0009-0001-7990-7857)
- Limei Sun
- Xiaoxiao Xu (ORCID: https://orcid.org/0000-0003-3884-8667)
- Yanting Lai
Institutions
- Sun Yat-sen University (CN)
- Sichuan University (CN)
- State Key Laboratory of Oral Diseases
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-03-19
- DOI
- https://doi.org/10.1167/iovs.66.3.39
- Primary Topic
- Corneal Surgery and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00