Complex Sepsis Presentations, SEP-1 Compliance, and Outcomes
In this cohort study of adults with sepsis, complex clinical presentations were more common among patients whose treatment was noncompliant with SEP-1. These nuances are poorly captured in most observational studies but confound the association between SEP-1 compliance and mortality.
Authors
- Laura DelloStritto
- Tingting Yu (ORCID: https://orcid.org/0000-0002-1628-5819)
- Anne Zepeski (ORCID: https://orcid.org/0000-0001-6309-6554)
- Michael Klompas (ORCID: https://orcid.org/0000-0001-8641-4498)
- Kamryn Plechot
- Steven T. Park
- Brett Faine (ORCID: https://orcid.org/0000-0002-5759-9857)
- Ezra Porter
- David J. Roach (ORCID: https://orcid.org/0000-0001-5199-0452)
- Chanu Rhee (ORCID: https://orcid.org/0000-0002-9537-4245)
- Nicholas M. Mohr (ORCID: https://orcid.org/0000-0003-0497-5828)
- Michael R. Filbin (ORCID: https://orcid.org/0000-0002-2588-7504)
- Sarah Train
- Claire Shappell (ORCID: https://orcid.org/0000-0002-8316-1496)
Institutions
- Brigham and Women's Hospital (US)
- University of Wisconsin–Madison (US)
- University of California, Irvine (US)
- Massachusetts General Hospital (US)
- University of California, Irvine Medical Center (US)
- Harvard Pilgrim Health Care (US)
- University of Iowa Health Care (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-03-19
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.1100
- Citations
- 5
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 6.77
Funders
- Centers for Disease Control and Prevention
- Agency for Healthcare Research and Quality
- University of California, Irvine