Exploring Acute Pancreatitis After Orlistat Use: A Case Report

Orlistat is an FDA-approved medication for obesity management that functions as a pancreatic lipase inhibitor. This medication is accessible without a prescription in numerous developed nations. As its utilization rises, the likelihood of experiencing adverse events also increases. A thorough understanding of these events is crucial for making informed decisions and ensuring effective management. We describe the case of a 23-year-old female who presented with acute pancreatitis after she started orlistat. We reviewed the association between orlistat use and acute pancreatitis, analyzing clinical cases and potential risk factors. By examining available medical literature and case studies, our study aims to provide insights into the correlation between orlistat therapy and the manifestation of acute pancreatitis.

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Publication Details

Journal
Cureus
Published
2025-03-19
DOI
https://doi.org/10.7759/cureus.80832
Primary Topic
Pancreatitis Pathology and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Exploring Acute Pancreatitis After Orlistat Use: A Case Report

Abhilasha Jyala, Elona Shehi, Haider Ghazanfar, Sarah Moore et al.
Cureus
Pancreatitis Pathology and Treatment
article

Exploring Acute Pancreatitis After Orlistat Use: A Case Report

Abhilasha Jyala, Elona Shehi, Haider Ghazanfar, Sarah Moore, Ornela Thartori, Abeer Qasim
article en

Abstract

Orlistat is an FDA-approved medication for obesity management that functions as a pancreatic lipase inhibitor. This medication is accessible without a prescription in numerous developed nations. As its utilization rises, the likelihood of experiencing adverse events also increases. A thorough understanding of these events is crucial for making informed decisions and ensuring effective management. We describe the case of a 23-year-old female who presented with acute pancreatitis after she started orlistat. We reviewed the association between orlistat use and acute pancreatitis, analyzing clinical cases and potential risk factors. By examining available medical literature and case studies, our study aims to provide insights into the correlation between orlistat therapy and the manifestation of acute pancreatitis.

CureusVol. 17(3)
Montefiore Health System (US), MemorialCare Health System (US)
Good health and well-being
Openalex Percentile: Top 91%
Pancreatitis Pathology and Treatment
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Exploring Acute Pancreatitis After Orlistat Use: A Case Report — Abhilasha Jyala, Elona Shehi, et al. · Cureus (2025) | TGRS Research Map | TGRS