Function of Transforming Growth Factor β2 and β3 in Palatogenesis
This study demonstrates that double siRNAs targeting TGF-β2 and -β3 results in phenotypes during secondary palatal fusion and that they could be affected phosphorylation of Smad-dependent and -independent signaling synergistically compared to single knockdown of TGF-β2 and -β3. The results of this study demonstrate important functions during secondary palatal fusion and will contribute to our understanding of the etiology of cleft palate.
Authors
- Mitsuru Motoyoshi (ORCID: https://orcid.org/0000-0001-8705-5757)
- Risako Okuma (ORCID: https://orcid.org/0009-0007-8311-5135)
- Akira Nakajima (ORCID: https://orcid.org/0000-0003-0056-9283)
- M. Aoki (ORCID: https://orcid.org/0000-0003-2244-2689)
- Charles F. Shuler
- Nichika Fukumashi
Institutions
- Nihon University (JP)
- University of British Columbia (CA)
Publication Details
- Journal
- Cells Tissues Organs
- Published
- 2025-03-19
- DOI
- https://doi.org/10.1159/000544097
- Citations
- 1
- Primary Topic
- Cleft Lip and Palate Research
- Type
- article
- Field-Weighted Citation Impact
- 1.82