Activin a regulates vascular formation and stabilization in direct coculture of dental pulp stem cells and endothelial cells
DPSC-HUVEC direct coculture upregulates Activin A secretion, interrupting VEGF receptors' balance in HUVECs to suppress HUVEC angiogenic sprouting and enhance vascular stabilization. These findings provide novel insights into the paracrine interactions on vascular stabilization of DPSC-HUVEC direct coculture.
Authors
- Jialin Zhong (ORCID: https://orcid.org/0000-0002-7813-1807)
- Ying Chen (ORCID: https://orcid.org/0000-0003-1615-7494)
- Qianzhou Jiang (ORCID: https://orcid.org/0000-0003-2631-7527)
- Jun Kang (ORCID: https://orcid.org/0000-0001-6692-1230)
- Yuchen Zhang (ORCID: https://orcid.org/0000-0003-3572-9830)
- Shulan Lin
- Mingxin Hu (ORCID: https://orcid.org/0000-0001-6757-9780)
- Junqing Liu
Institutions
- Stomatology Hospital (CN)
- Third Affiliated Hospital of Zhengzhou University (CN)
- University of Hong Kong (HK)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- International Endodontic Journal
- Published
- 2025-03-19
- DOI
- https://doi.org/10.1111/iej.14226
- Citations
- 1
- Primary Topic
- Periodontal Regeneration and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.84
Funders
- National Natural Science Foundation of China
- Science, Technology and Innovation Commission of Shenzhen Municipality