Chemical Constituents with Ferroptosis Inhibitory Activity of the Deep‐Sea‐Derived <i>Penicillium paxilli</i>
A rare tri-nor-non-paspaline indole diterpenoid (penpaxin A, 1), a new 1,3-dioxolane derivative (penpaxin B, 9), and 19 known compounds (2-8 and 10-21) were isolated from the deep-sea-derived Penicillium paxilli MCCC 3A01133. The structures of the new compounds were established by detailed analyses of the NMR, HRESIMS, and ORD data. 3-Deoxo-4b-deoxypaxilline (5) and paspaline (7) exhibited potent inhibition on RSL3-induced ferroptosis with the EC<sub>50</sub> values of 2.88 and 0.21 µM, respectively.
Authors
- Xian‐Wen Yang (ORCID: https://orcid.org/0000-0002-4967-0844)
- Taizong Wu (ORCID: https://orcid.org/0000-0002-1817-6018)
- Rong Chao
- Zhuoneng Chen (ORCID: https://orcid.org/0000-0001-6984-1383)
- Tian‐Hua Zhong (ORCID: https://orcid.org/0009-0002-0342-6253)
- Bin Wang (ORCID: https://orcid.org/0000-0002-2712-9045)
- Yuan Wang (ORCID: https://orcid.org/0009-0001-8115-8699)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Chinese University of Hong Kong, Shenzhen (CN)
- Fujian Institute of Oceanography (CN)
- Hainan Medical University (CN)
Publication Details
- Journal
- Chemistry & Biodiversity
- Published
- 2025-03-19
- DOI
- https://doi.org/10.1002/cbdv.202500540
- Citations
- 1
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 1.39