A polygenic score for height identifies an unmeasured genetic predisposition among pediatric patients with idiopathic short stature
Some children with ISS-NF have an unrecognized polygenic predisposition to shorter height, similar to children with ISS-F and greater than those with growth disorders. A PGS<sub>height</sub> could aid clinicians in identifying children with a benign, polygenic predisposition to shorter height.
Authors
- Jill H. Simmons
- Sara L. Van Driest (ORCID: https://orcid.org/0000-0003-2580-1405)
- Mingjian Shi (ORCID: https://orcid.org/0000-0003-1569-9822)
- Josh F. Peterson (ORCID: https://orcid.org/0000-0002-7553-0749)
- Jonathan D. Mosley
- John P. Shelley
Institutions
- Henry M. Jackson Foundation (US)
- National Institutes of Health (US)
- Uniformed Services University of the Health Sciences (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Genome Medicine
- Published
- 2025-03-19
- DOI
- https://doi.org/10.1186/s13073-025-01455-3
- Citations
- 4
- Primary Topic
- Growth Hormone and Insulin-like Growth Factors
- Type
- article
- Field-Weighted Citation Impact
- 5.18
Funders
- National Human Genome Research Institute
- National Institute of General Medical Sciences