The application of magnetic susceptibility separation for measuring cerebral oxygenation in preterm neonates
This study evaluated the use of QSM and its paramagnetic components to measure cerebral oxygenation in neonates. By comparing susceptibility-derived oxygen saturation (SvO<sub>2</sub>) in the superior sagittal sinus (SSS) and central cerebral veins (CCV), it adds to the field of neonatal cerebral oxygenation measurement. Decomposing QSM into paramagnetic components shows potential for improving SvO<sub>2</sub> accuracy, particularly in the SSS, though variability remains a challenge. The results suggest no significant oxygenation difference between the SSS and CCV, contrasting with previous findings, indicating a need for further research on neonatal venous oxygenation.
Authors
- Ruth E. Grunau (ORCID: https://orcid.org/0000-0002-5428-9212)
- Alexander Mark Weber (ORCID: https://orcid.org/0000-0001-7295-0775)
- Alexander Rauscher (ORCID: https://orcid.org/0000-0002-1961-8252)
- Thomas Gavin Carmichael
Institutions
- University of British Columbia (CA)
- BC Children's Hospital (CA)
Publication Details
- Journal
- Pediatric Research
- Published
- 2025-03-19
- DOI
- https://doi.org/10.1038/s41390-025-03966-6
- Citations
- 2
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 2.72
Funders
- BC Children's Hospital