Single-Cell and Spatial Transcriptomics Reveal a Tumor-Associated Macrophage Subpopulation that Mediates Prostate Cancer Progression and Metastasis
This study expands our understanding of the diverse roles of macrophage populations in prostate cancer metastases and highlights new therapeutic targets.
Authors
- Shenglin Mei (ORCID: https://orcid.org/0000-0001-8258-5898)
- Douglas M. Dahl (ORCID: https://orcid.org/0000-0002-9084-9627)
- Yanxin Xu (ORCID: https://orcid.org/0000-0003-3651-6909)
- Ninib Baryawno (ORCID: https://orcid.org/0000-0001-6054-4163)
- Chin‐Lee Wu (ORCID: https://orcid.org/0000-0002-0444-0068)
- Taghreed Hirz (ORCID: https://orcid.org/0000-0001-9230-1756)
- Philip J. Saylor (ORCID: https://orcid.org/0000-0003-4849-3695)
- Akash Patnaik (ORCID: https://orcid.org/0000-0001-5306-0208)
- Shulin Wu (ORCID: https://orcid.org/0000-0002-2333-3700)
- David B. Sykes (ORCID: https://orcid.org/0000-0002-9788-0221)
- Nathan Elias Jeffries
- Hanyu Zhang (ORCID: https://orcid.org/0000-0003-2259-1721)
Institutions
- Boston University (US)
- Harvard University (US)
- American Institute for Cancer Research (US)
- Harvard University Press (US)
- Karolinska Institutet (SE)
- Virginia–Maryland College of Veterinary Medicine (US)
- University of Chicago (US)
- Massachusetts General Hospital (US)
- Center for Cancer Research (US)
- Virginia Tech (US)
Publication Details
- Journal
- Molecular Cancer Research
- Published
- 2025-03-19
- DOI
- https://doi.org/10.1158/1541-7786.mcr-24-0791
- Citations
- 14
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 14.64