Detection of Anti‐Non‐α‐Gal Xenoreactive Antibodies in Human Blood Products
Both FFP and cryo contain IgM and IgG non-galactose-α-1,3-galactose (αGal) xenoantibodies capable of killing GTKO PBMCs, though the level varies by preparation. Although some centers utilize a genetic background with mutations in the three enzymes responsible for the known xenoantigens, others are investigating the GTKO pig as a potential option. These results suggest that a center pursuing a human xenotransplantation study with a GTKO genetic background should pre-screen blood products prior to administration.
Authors
- Jean Kwun (ORCID: https://orcid.org/0000-0002-8563-5472)
- Annette M. Jackson (ORCID: https://orcid.org/0000-0003-2648-2944)
- Janghoon Yoon (ORCID: https://orcid.org/0000-0001-8543-194X)
- Joseph M. Ladowski (ORCID: https://orcid.org/0000-0002-6787-3725)
- Meghan Hu
- Stuart J. Knechtle (ORCID: https://orcid.org/0000-0002-1625-385X)
- Zheng Chen (ORCID: https://orcid.org/0009-0001-8217-8595)
Institutions
- Duke University (US)
Publication Details
- Journal
- Xenotransplantation
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1111/xen.70034
- Citations
- 5
- Primary Topic
- Xenotransplantation and immune response
- Type
- article
- Field-Weighted Citation Impact
- 10.03
Funders
- American Society of Transplant Surgeons
- National Synchrotron Radiation Research Center
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases