Effect of albumin treatment duration on response rates and outcomes in patients with cirrhosis and acute kidney injury
This study provides valuable insights into the optimal duration of albumin treatment for patients with cirrhosis and acute kidney injury, challenging the recent recommendation to shorten the duration of albumin treatment. Furthermore, the optimal definition for response to albumin (reduction of at least one acute kidney injury stage) has been assessed. The results of this study are highly clinically relevant since shortening albumin therapy may lead to overtreatment with terlipressin, and evidence to support a specific definition of response to albumin was lacking. Clinicians can use these findings to predict treatment outcomes better, avoid fluid overload, and improve patient prognosis, while also considering the potential risks of early intervention with terlipressin.
Authors
- Christian Labenz (ORCID: https://orcid.org/0000-0001-8390-9663)
- Alexander Zipprich (ORCID: https://orcid.org/0000-0001-8403-7983)
- Cristina Ripoll (ORCID: https://orcid.org/0000-0002-9704-4741)
- Simon Johannes Gairing (ORCID: https://orcid.org/0000-0003-3240-5152)
- Eva Maria Schleicher
- Julia Weinmann‐Menke (ORCID: https://orcid.org/0000-0001-7344-8381)
- Peter R. Galle (ORCID: https://orcid.org/0000-0001-8294-0992)
- Andreas Stallmach (ORCID: https://orcid.org/0000-0002-6101-5244)
- Henrik Karbannek (ORCID: https://orcid.org/0009-0002-5992-7372)
Institutions
- Johannes Gutenberg University Mainz (DE)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- Jena University Hospital (DE)
- Friedrich Schiller University Jena (DE)
Publication Details
- Journal
- Journal of Hepatology
- Published
- 2025-03-19
- DOI
- https://doi.org/10.1016/j.jhep.2025.03.008
- Citations
- 7
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 9.25