Identifying Data-Driven Clinical Subgroups for Cervical Cancer Prevention With Machine Learning: Population-Based, External, and Diagnostic Validation Study
This study underscores the potential of leveraging machine learning algorithms and large-scale routine electronic health records to enhance CCP strategies. By identifying key determinants of CIN2+/CIN3+ risk and classifying 5 distinct subgroups, our study provides a robust, data-driven foundation for the proposed triple strategy. This approach prioritizes tailored prevention efforts for subgroups with varying risks, offering a novel and scalable tool to complement existing cervical cancer screening guidelines. Future work should focus on independent external and prospective validation to maximize the global impact of this strategy.
Authors
- Bingyi Wang (ORCID: https://orcid.org/0000-0002-3713-0488)
- Juntao Wang (ORCID: https://orcid.org/0000-0001-6097-9079)
- Weijie Zhang (ORCID: https://orcid.org/0009-0003-0582-5255)
- Shuxia Xu (ORCID: https://orcid.org/0000-0001-8163-9145)
- Pengming Sun (ORCID: https://orcid.org/0000-0002-5072-6091)
- Binhua Dong (ORCID: https://orcid.org/0000-0002-5086-0696)
- Xunyuan Tuo
- Xinxin Huang (ORCID: https://orcid.org/0000-0002-3611-3061)
- Huachun Zou (ORCID: https://orcid.org/0000-0002-8161-7576)
- Leiwen Fu (ORCID: https://orcid.org/0000-0003-3959-5788)
- Junfeng Wang (ORCID: https://orcid.org/0000-0001-5157-5355)
- Zhen Lu (ORCID: https://orcid.org/0000-0002-3481-6310)
- Tian Tian (ORCID: https://orcid.org/0000-0002-6103-1666)
- Zheng Zheng
- Siyang Liu
- Huifeng Xue (ORCID: https://orcid.org/0000-0001-8338-0296)
- Hongning Cai (ORCID: https://orcid.org/0000-0002-4700-2754)
- Shanshan Lin
- Tianjie Yang
Institutions
- Fujian Medical University (CN)
- Xinjiang Medical University (CN)
- Sun Yat-sen University (CN)
- Capital Medical University (CN)
- Utrecht University (NL)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Fudan University (CN)
- Peking Union Medical College Hospital (CN)
- Fujian Women and Children Hospital (CN)
- Foshan Maternity and Child Health Care Hospital (CN)
- The First People's Hospital of Shunde (CN)
- Shenzhen Maternity and Child Healthcare Hospital (CN)
- Beijing Chest Hospital (CN)
- Gansu Provincial Maternal and Child Health Hospital (CN)
- Hubei Provincial Women and Children's Hospital (CN)
- Fuzhou Maternity and Child Health Care Hospital (CN)
- Guangdong Provincial Center for Disease Control and Prevention (CN)
Publication Details
- Journal
- JMIR Public Health and Surveillance
- Published
- 2025-03-19
- DOI
- https://doi.org/10.2196/67840
- Citations
- 4
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 5.42