Cost-effectiveness of broadly neutralizing antibodies for HIV prophylaxis for infants born in settings with high HIV burdens
Adding long-acting bNAbs to current standard-of-care prophylaxis would be cost-effective, assuming plausible efficacies and costs. The cost-effective target population would vary by setting, largely driven by maternal antenatal HIV prevalence and postpartum incidence.
Authors
- Patricia Fast
- Elizabeth J. McFarland (ORCID: https://orcid.org/0000-0003-0653-8955)
- Adrie Bekker (ORCID: https://orcid.org/0000-0003-3836-3432)
- Shelly Malhotra (ORCID: https://orcid.org/0000-0002-7457-386X)
- Genevieve G. Fouda (ORCID: https://orcid.org/0000-0002-0960-1019)
- Lusine Ghazaryan (ORCID: https://orcid.org/0000-0001-7219-333X)
- Roger Shapiro (ORCID: https://orcid.org/0000-0002-4832-6275)
- Carlyn Mann (ORCID: https://orcid.org/0000-0001-6445-507X)
- Ameena Goga (ORCID: https://orcid.org/0000-0002-2394-6486)
- Lynda Stranix‐Chibanda (ORCID: https://orcid.org/0000-0003-3566-1688)
- Christopher Alba (ORCID: https://orcid.org/0000-0001-8692-7656)
- Devin Sok (ORCID: https://orcid.org/0000-0002-9354-1740)
- Coleen K. Cunningham (ORCID: https://orcid.org/0000-0002-7725-3052)
- Caitlin M. Dugdale (ORCID: https://orcid.org/0000-0002-6604-6111)
- Sallie R. Permar (ORCID: https://orcid.org/0000-0003-1438-4554)
- Valériane Leroy (ORCID: https://orcid.org/0000-0003-3542-8616)
- S. Horsfall (ORCID: https://orcid.org/0009-0005-1135-0262)
- Vincent Muturi‐Kioi (ORCID: https://orcid.org/0000-0003-1620-3999)
- Margaret McCluskey
- Andrea Ciaranello (ORCID: https://orcid.org/0000-0002-4268-3263)
- Kenneth A. Freedberg (ORCID: https://orcid.org/0000-0003-3143-7822)
- Matthew E. Barnhart
- Milton C. Weinstein
- Katerina Chapman (ORCID: https://orcid.org/0000-0001-5413-2058)
Institutions
- South African Medical Research Council (ZA)
- Scripps Research Institute (US)
- Children's Hospital of Orange County (US)
- International AIDS Vaccine Initiative (US)
- Beth Israel Deaconess Medical Center (US)
- Université Toulouse III - Paul Sabatier (FR)
- Harvard University (US)
- University of Zimbabwe (ZW)
- Inserm (FR)
- University of California, Irvine (US)
- Cornell University (US)
- Stellenbosch University (ZA)
- United States Agency for International Development (US)
- Massachusetts General Hospital (US)
- Children's Hospital Colorado (US)
- Presbyterian Hospital (US)
- University of Colorado Anschutz Medical Campus (US)
- University of Pretoria (ZA)
- University of Colorado Denver (US)
- Stanford University (US)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-03-19
- DOI
- https://doi.org/10.1371/journal.pone.0318940
- Citations
- 3
- Primary Topic
- HIV/AIDS Research and Interventions
- Type
- article
- Field-Weighted Citation Impact
- 4.19
Funders
- U.S. President’s Emergency Plan for AIDS Relief
- International Maternal Pediatric Adolescent AIDS Clinical Trials Network
- National Institute of Allergy and Infectious Diseases
- Eunice Kennedy Shriver National Institute of Child Health and Human Development