The association between adult-life smoking and age-related cognitive decline in Danish men
Smoking explained negligible fractions of the variance in cognitive decline, and thus our results did not indicate that smoking is a strong predictor of cognitive decline. The effects of pack-years suggest a relatively weak, possibly cumulative effect of smoking across the adult lifespan. The difference in decline between smokers and non-smokers may reflect participation bias and selective attrition at follow-up while the effects of current smoking may reflect either temporary effects of smoking or individual and life-style characteristics associated with continuation of smoking into late midlife.
Authors
- Erik Lykke Mortensen (ORCID: https://orcid.org/0000-0002-6985-451X)
- Trine Flensborg‐Madsen (ORCID: https://orcid.org/0000-0002-6753-335X)
- Marie Grønkjær (ORCID: https://orcid.org/0000-0002-7049-0952)
- Lonny Stokholm (ORCID: https://orcid.org/0000-0002-9727-6649)
- Kristine Hell
Institutions
- University of Copenhagen (DK)
- University of Southern Denmark (DK)
- Frederiksberg Hospital (DK)
- Copenhagen University Hospital (DK)
- Center for Clinical Research and Prevention (DK)
- National Research Centre for the Working Environment (DK)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-03-19
- DOI
- https://doi.org/10.1371/journal.pone.0319839
- Primary Topic
- Health, Environment, Cognitive Aging
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Innovationsfonden
- Lundbeckfonden
- Helsefonden
- Læge Sophus Carl Emil Friis og hustru Olga Doris Friis' Legat
- Faculty of Health and Medical Sciences, University of Western Australia
- Danmarks Frie Forskningsfond
- H. Lundbeck A/S
- Det Sundhedsvidenskabelige Fakultet, Københavns Universitet