Ultrafast laser 3D and volume processing

We applied the 3D fabrication capability of ultrafast laser to fabricate 3D functional micro and nanodevices for chemical and biological applications. Applications of the fabricated devices include 3D micro and nanofluidic systems to elucidate mechanism of cancer cell metastasis and invasion in the human body, diagnostic microchips based on advanced digital nucleic acid amplification technique (d-NAAT), such as digital polymerase chain reaction (d-PCR), which consists of an array of more than 10,000 micro-through-holes on glass substrates, and 3D microfluidic surface enhanced Raman spectroscopy (SERS) chips enabling real-time sensing and attomolar level sensing of chemical and biological samples.