Unveiling the crucial role of CD8+ T cell and endothelial cell interaction in rheumatoid arthritis through the integrated analysis of spatial transcriptomics and bulk/single-cell RNA-seq
This study highlight CD8<sup>+</sup> T cell- EC interactions via chemokine signaling as critical drivers of RA progression, potentially promoting leukocyte transendothelial migration and synovial immune infiltration.
Authors
- Zishao Zhong
- Hudan Pan
- Tuliang Liang
- Xizi He (ORCID: https://orcid.org/0000-0002-9130-1321)
- Chuanhai Zhang (ORCID: https://orcid.org/0000-0001-7644-2436)
- Yao Xiao (ORCID: https://orcid.org/0000-0002-3078-7225)
- Liang Liu (ORCID: https://orcid.org/0000-0001-8630-7430)
- Yuan Liu (ORCID: https://orcid.org/0000-0003-4783-5905)
- Yu Lai
- Hao Yu (ORCID: https://orcid.org/0000-0001-9119-6114)
- Runze Li (ORCID: https://orcid.org/0009-0005-8759-1783)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- University of Macau (MO)
- Key Laboratory of Guangdong Province (CN)
- Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine (CN)
Publication Details
- Journal
- Journal of Translational Autoimmunity
- Published
- 2025-03-19
- DOI
- https://doi.org/10.1016/j.jtauto.2025.100285
- Citations
- 2
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 3.34