The MNK-SYNGAP1 axis in specific learning disorder: gene expression pattern and new perspectives
• This study is the first to demonstrate significant upregulation of SYNGAP1 and MKNK1 in children with SLD. • Understanding the role of the MKNK-SYNGAP1 axis may guide the development of targeted therapies aimed at enhancing synaptic plasticity to improve learning and memory outcomes in children with SLD.
Authors
- Nil Özbilüm Şahin (ORCID: https://orcid.org/0000-0002-2889-3600)
- Cansu Mercan Işık (ORCID: https://orcid.org/0000-0001-9437-3024)
- Elif Burcu Tuzemen Bayyurt
Institutions
- Sivas Cumhuriyet Üniversitesi (TR)
Publication Details
- Journal
- European Journal of Pediatrics
- Published
- 2025-03-19
- DOI
- https://doi.org/10.1007/s00431-025-06089-6
- Citations
- 7
- Primary Topic
- Genetics and Neurodevelopmental Disorders
- Type
- article
- Field-Weighted Citation Impact
- 12.72
Funders
- Sivas Cumhuriyet Üniversitesi