Spike Protein–Fibrinogen Interaction: A Novel Immune Evasion Strategy of SARS-CoV-2?
The host protein fibrinogen has been found to interact with the N-terminal domain (NTD) of the spike protein in SARS-CoV-2. However, the evolutionary benefit of this binding to the virus still remains unclear. Herein, we put forward with rationale and supporting evidence that the binding of fibrinogen to its more conserved NTD is an immune evasion strategy adopted by the virus to outsmart the NTD targeted neutralizing antibodies.
Authors
- Shashi Bala Singh (ORCID: https://orcid.org/0000-0002-1793-2619)
- Saroj Kumar Panda (ORCID: https://orcid.org/0000-0002-5353-0393)
- Parth Sarthi Sen Gupta (ORCID: https://orcid.org/0000-0002-3083-3957)
Institutions
- The University of Texas at Arlington (US)
- D Y Patil International University (IN)
Publication Details
- Journal
- ACS Pharmacology & Translational Science
- Published
- 2025-03-19
- DOI
- https://doi.org/10.1021/acsptsci.5c00122
- Citations
- 3
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 4.19