Transient Inhibition of the Mediodorsal Thalamus During Early Adolescence Induces Hypofrontality and Social Memory Deficits in Young Adulthood
Our findings provide insights into the role of MD input activity in shaping the circuit and functional maturation of the mPFC that is critical for the normal development of social memory and abnormal deficits in psychiatric disorders.
Authors
- Wen‐Jun Gao (ORCID: https://orcid.org/0000-0002-8585-3082)
- Liang Chen (ORCID: https://orcid.org/0000-0003-0968-2936)
- S. Liu (ORCID: https://orcid.org/0000-0003-3866-9095)
- Ke Wei (ORCID: https://orcid.org/0000-0001-8542-2146)
- Quansheng He
- Yousheng Shu (ORCID: https://orcid.org/0000-0002-2834-2876)
- Bo Li (ORCID: https://orcid.org/0000-0002-0154-3088)
- Sha-Sha Yang
- Xinyang Gu
Institutions
- Fudan University (CN)
- Huashan Hospital (CN)
- Drexel University (US)
Publication Details
- Journal
- Biological Psychiatry Global Open Science
- Published
- 2025-03-19
- DOI
- https://doi.org/10.1016/j.bpsgos.2025.100486
- Citations
- 2
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- National Natural Science Foundation of China
- Fudan University
- Science and Technology Commission of Shanghai Municipality
- National Outstanding Youth Science Fund Project of National Natural Science Foundation of China
- National Institute of Mental Health