Inhibition of Endoplasmic Reticulum Oxidoreductin 1 Modulates Neuronal Excitability and Nociceptive Sensitivity in Mice
This study found that ERO1 inhibition dampens mitochondrial function, sensory neuron excitability, and acute pain-like behavior in mice. Additionally, ERO1 inhibition decreases sensory neuron excitability in post-mortem human sensory neurons in vitro. The results indicate that targeting ERO1 may be a viable strategy for non-narcotic acute pain relief.
Authors
- Jayadeep Rao (ORCID: https://orcid.org/0000-0001-8330-7400)
- Thomas Simmen (ORCID: https://orcid.org/0000-0002-2350-2965)
- Kathleen H. Goss (ORCID: https://orcid.org/0000-0002-7379-5639)
- Jason R. Plemel (ORCID: https://orcid.org/0000-0003-1385-1464)
- Sridhar Reddy Kaulagari (ORCID: https://orcid.org/0000-0001-9055-2973)
- Harley T. Kurata (ORCID: https://orcid.org/0000-0003-4357-4189)
- Anna M.W. Taylor (ORCID: https://orcid.org/0000-0001-7881-8783)
- Lori Hazlehurst (ORCID: https://orcid.org/0000-0001-7040-4084)
- Gustavo Tenorio
- Muhammad Saad Yousuf (ORCID: https://orcid.org/0000-0003-0829-8182)
- Aislinn D. Maguire (ORCID: https://orcid.org/0000-0003-4622-4598)
- Shawn M. Lamothe (ORCID: https://orcid.org/0000-0001-8722-2631)
- Bradley J. Kerr (ORCID: https://orcid.org/0000-0002-0264-8316)
Institutions
- West Virginia University (US)
- University of Alberta (CA)
- The University of Texas at Dallas (US)
- Women and Children’s Health Research Institute (CA)
- Modulation Therapeutics (United States) (US)
Publication Details
- Journal
- Anesthesiology
- Published
- 2025-03-19
- DOI
- https://doi.org/10.1097/aln.0000000000005453
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00