Extracellular NAD+ levels are associated with CD203a expression on Th17 cells and predict long-term recurrence-free survival in hepatocellular carcinoma
The data indicates that eNAD<sup>+</sup> levels are decreased in patients with liver fibrosis or cirrhosis. Strikingly, patients with high CD203a expression on Th17 cells had a significantly increased likelihood of recurrence, highlighting its potential as a valuable prognostic marker and a possible therapeutic target.
Authors
- Felix Krenzien (ORCID: https://orcid.org/0000-0003-0593-9917)
- Can Kamali (ORCID: https://orcid.org/0000-0003-1190-6775)
- Eriselda Keshi (ORCID: https://orcid.org/0000-0002-1780-9151)
- Philipp Brunnbauer
- Sebastian Knitter (ORCID: https://orcid.org/0000-0001-9232-6793)
- Wenzel Schöning (ORCID: https://orcid.org/0000-0002-0446-5126)
- Matthäus Felsenstein (ORCID: https://orcid.org/0000-0003-3146-8717)
- Philipp Haber
- Johann Pratschke (ORCID: https://orcid.org/0000-0001-9839-1369)
- Julia Babigian (ORCID: https://orcid.org/0009-0005-7013-5896)
- Isis Lozzi
Institutions
- Humboldt-Universität zu Berlin (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Freie Universität Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Journal of Cancer Research and Clinical Oncology
- Published
- 2025-03-19
- DOI
- https://doi.org/10.1007/s00432-025-06155-4
- Citations
- 1
- Primary Topic
- Adenosine and Purinergic Signaling
- Type
- article
- Field-Weighted Citation Impact
- 1.12
Funders
- Charité – Universitätsmedizin Berlin