HFIP-Promoted Aromatic Electrophilic Amidation of Indoles and Pyrroles with Isocyanates
A mild and practical method for synthesizing amidoindoles and amidopyrroles was described via the direct amidation of indoles or pyrroles with isocyanates promoted by 1,1,1,3,3,3-hexafluoroisopropanol (HFIP). In this reaction, HFIP acted as a strong hydrogen bond-donating solvent to activate isocyanates, enabling the amidation of electron-rich nitrogen-containing heterocycles.
Authors
- Liang-Bi Chen (ORCID: https://orcid.org/0000-0003-3181-4480)
- Chao Li (ORCID: https://orcid.org/0000-0002-4725-8661)
- Jiaxing Li (ORCID: https://orcid.org/0000-0002-7683-2482)
- Song Song (ORCID: https://orcid.org/0000-0001-6679-1982)
- Hongye Wang (ORCID: https://orcid.org/0000-0002-2926-8305)
Institutions
- Peking University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-03-19
- DOI
- https://doi.org/10.1021/acs.joc.4c03176
- Citations
- 2
- Primary Topic
- Chemical Synthesis and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China
- Peking University