Impact of measles virus infection on immune signaling pathways in human lung cancer cell lines

The measles virus is an aerosol-transmitted virus that kills a considerable number of people and infects a lot of youngsters every year. It was formerly thought to replicate in the respiratory epithelium before spreading, however it was recently demonstrated to use signaling lymphocytic activation molecule family member 1 as a receptor to first infect macrophages and dendritic cells of the airways. After passing through the respiratory epithelium, these cells carry the infection to lymphatic organs where the measles virus multiplies rapidly. Thus, we decided to select the publicly available dataset which are related to measles infection where we had seven different types of cell lines and performed in-silico analysis of the gene expression patterns and the altered signaling pathways and finally, compared them between the cell lines. The potential focus of the study was to understand the impact on immune signaling pathways and their components. Here, we observe that there are a significant number of genes and the pathways potentially altered as a result of measles infection. Based on our results, we conclude that APC, RAP1, NK cell, cAMP, RAS, TNF, and neuroactive ligand-receptor signaling are among the leading altered pathways.