Mechanobiology of glioblastoma spheroids: evaluation using nanobomb optical coherence elastography and Brillouin microscopy
Mechanobiology of Glioblastoma Spheroids: Evaluation using Nanobomb Optical Coherence Elastography and Brillouin Microscopy Maryam Hatami1, Megan Mendieta1, Manmohan Singh1, Sajedeh Saeidi Fard1, Mohammad Dehshiri1, Alexander W. Schill1, Dmitry Nevozhay2, Salavat Aglyamov3, Bulent Ozpolat4, Konstantin V. Sokolov2,5, Yasemin M. Akay1, Metin Akay1, and Kirill V. Larin1, * This study presents the novel application of nanobomb optical coherence elastography (nb-OCE) and Brillouin microscopy to assess the biomechanical characteristics of glioblastoma multiforme (GBM) spheroids. LN229 glioblastoma cells were cultured and treated with temozolomide (TMZ). A significant decrease in spheroid stiffness and size was observed as a result of the treatment, suggesting increase
Authors
- Konstantin Sokolov (ORCID: https://orcid.org/0000-0002-0198-2005)
- Metin Akay (ORCID: https://orcid.org/0000-0002-2988-4669)
- Manmohan Singh (ORCID: https://orcid.org/0000-0002-8396-5451)
- Alexander Schill
- Yasemin M. Akay (ORCID: https://orcid.org/0000-0003-1753-6293)
- Mohammad Dehshiri
- Sajedeh Saeidi Fard (ORCID: https://orcid.org/0000-0002-0614-1117)
- Kirill V. Larin (ORCID: https://orcid.org/0000-0002-5532-5027)
- Dmitry Nevozhay (ORCID: https://orcid.org/0000-0003-3887-6481)
- Salavat R. Aglyamov (ORCID: https://orcid.org/0000-0001-9530-1225)
- Megan Mendieta (ORCID: https://orcid.org/0009-0003-3012-8793)
- Bulent Ozpolat (ORCID: https://orcid.org/0000-0003-1190-9255)
- Maryam Hatami (ORCID: https://orcid.org/0000-0002-4165-3214)
Publication Details
- Published
- 2025-03-19
- DOI
- https://doi.org/10.1117/12.3047711
- Primary Topic
- Cellular Mechanics and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00