Impact of active alignment on long-term pointing stability of laser engine in flow cytometry

The core of a flow cytometry system is its laser engine, which is meant to deliver stable, high-quality laser light to the flow cell. Stability and longevity of the laser core are crucial, as long-term drift laser drift leads to the need in regular servicing. We developed a laser engine with active beam alignment, driven by AI algorithms, to maintain beam position stability over time. This technology actively steers the beam, compensating for potential short- and long-term drift. This paper evaluates the effectiveness of active alignment through comparative analysis of beam pointing stability with and without this feature, demonstrating reduced servicing needs and enhanced system performance.

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Published
2025-03-19
DOI
https://doi.org/10.1117/12.3040034
Primary Topic
Remote Sensing and LiDAR Applications
Type
article
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article

Impact of active alignment on long-term pointing stability of laser engine in flow cytometry

Petteri Uusimaa, Kostiantyn Nechay, Anna Essaulova, Sergei Kühn
Remote Sensing and LiDAR Applications
article

Impact of active alignment on long-term pointing stability of laser engine in flow cytometry

Petteri Uusimaa, Kostiantyn Nechay, Anna Essaulova, Sergei Kühn
article en

Abstract

The core of a flow cytometry system is its laser engine, which is meant to deliver stable, high-quality laser light to the flow cell. Stability and longevity of the laser core are crucial, as long-term drift laser drift leads to the need in regular servicing. We developed a laser engine with active beam alignment, driven by AI algorithms, to maintain beam position stability over time. This technology actively steers the beam, compensating for potential short- and long-term drift. This paper evaluates the effectiveness of active alignment through comparative analysis of beam pointing stability with and without this feature, demonstrating reduced servicing needs and enhanced system performance.

Modulight (Finland) (FI)
Affordable and clean energy
Openalex Percentile: Top 95%
Remote Sensing and LiDAR Applications
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