Translational efforts for digital chemical pathology with infrared laser scanning microscopy
Chemical imaging (CI) techniques based on infrared (IR) spectroscopic imaging have seen tremendous interest in recent years, leading to an abundance of on-going research designing new instrumentation. Our technology builds on a recently reported laser scanning confocal microscope design capable of in-the-field imaging of whole slides with consistently high-throughput, low-noise, and high resolution. We in-source the design of optics, software, and mechanics, enabling end-users access to chemical imaging of biological samples and more with AI analytics, while providing developers a new mid-IR compatible platform to expand upon. We discuss current efforts to realize this technology for clinical and research interests.
Authors
- Matthew Phelan Confer (ORCID: https://orcid.org/0000-0002-0856-3583)
- Yen‐Ting Liu (ORCID: https://orcid.org/0000-0002-5768-0516)
- Rohit Bhargava (ORCID: https://orcid.org/0000-0001-7360-994X)
- Ruo-Jing Ho (ORCID: https://orcid.org/0000-0003-4181-3262)
- Kianoush Falahkheirkhah (ORCID: https://orcid.org/0000-0003-2781-2693)
- Kevin Yeh (ORCID: https://orcid.org/0000-0002-7012-7483)
- Ishaan Sharma (ORCID: https://orcid.org/0009-0004-7498-5444)
- Andres C. Orr
- Mykolas Tamonis
Institutions
- University of Illinois System (US)
- Chan Zuckerberg Biohub San Francisco (US)
Publication Details
- Published
- 2025-03-19
- DOI
- https://doi.org/10.1117/12.3043508
- Primary Topic
- Infrared Thermography in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00